Whilst I'm sure this is possible I would like to point out a different but potentially very serious problem with that setup. I recently ran my PODXT live into a spider amp at a rehearsal room. I tweaked all the settings; tone correction, set it to stack front and cranked the output. I was greeted with an incredibly weak signal that couldnt be heard over the drums. Everything at 10 and it didnt cut it. I havent had that problem running into marshall or vox amps so it must have been the spider! I didnt try using the studio direct setting in front of the amp, so maybe this would help but i doubt it. There was also no effect return on the spider, so that wasnt an option. I was shocked to find that line 6 gear would be so incompatible! Buyer beware.