Hi,
From that brief description, it seems like a USB connectivity issue. If so, please try a different USB port then reopen GearBox, try removing any USB hub if you have one (even if the L6 device ISNT connected to it). Also be sure to disable any firewalls & virus checkers.
If this does not solve it, please reply with more information on your system by completing a support profile here: http://line6.com/account/supportprofile/
Thanks
Line6Sach