Do not connecttwo Vyzex compatible Line 6 devices to one computer at the same time while using the Vyzex software. Performing edits in the Vyzex software while two Vyzex compatible Line 6 devices are connected to the computer at the same time can cause a serious conflict that could corrupt the flash RAM of the receiving device.
Additional information from Psicraft Designs:
The issue described in this document is that PocketPOD, FloorPOD Plus and even POD 2.0 share the same SysEx Device ID - This means you should only use the Vyzex PocketPOD editor with PocketPOD, the Vyzex FloorPOD Plus editor with FloorPOD Plus, and our soon to be released Vyzor POD 2.0 editor with POD 2.0, since the devices themselves will accept any parameter dumps intended for the similar but ultimately different products.
If you simply have to edit two or more of these devices simultaneously, you'll need to configure each of the editors to only open the specific MIDI ports used by the correct instrument - By default Vyzex and Vyzor editors open all MIDI ports on your machine to make autosensing possible, but you can override this feature in the program preferences and simply have each editor 'hard-wired' to the correct MIDI ports on your system. Taking this extra step will make multiple editor/device editing possible between separate editors and multiple POD class instruments.