what i did with my set up was prepare a different bank for each guitar. like say,bank1 for the strat, bank2 for the tele..etc. use the same patches in each bank but tweak them to sound as close to the same as you can. so when you switch to your tele all you have to do is switch banks. and so on. with the amp setup I always embrace a bit of a difference in sound from amp to amp. im the only guitarist in my band so i tend to try to get different tones for each side of the stage. i now use a pod pro into a randall rg150 es on stage left where i stand. and then i have a spider3 on stage right. ill dial in the randall for i good basic rhythm tone as my main output. then have a little higher and brighter tone on stage right for a good lead sound. with the two different setups i have separate control over each amps volume too. because i have a floorboard for the pod pro,and a fbv express for the spider. so i hope this helps a bit one way or the other. have a good day and have fun chasin the almighty tone! : )