It sounds like shifting through radio frequencies on some models.
This is on custom bank 2, guitar is stock new, i just updated to latest firmware. Lester bank, bridge position also has this kind of noise.
I had the exact same problem last year and reported it to Line6 and after investigating the problem for me they agreed it was faulty and replaced it with a brand new guitar.
See thread: http://uk.line6.com/support/message/324035#324035 and read entries from 20 Sep 2011.
If this is a new guitar send it back to retailer and ask for a replacement. If you have problems with retailer then contact Line 6 directly by phone and they will resolve for you.