Whenever I play lower notes or chords (anything on the low E or A strings) I get an unwanted low frequency resonance.

A "flub" for lack of a better term.

It's more of an issue when using "hi gain" tones, but happens with lower gain and cleans tones, just not nearly as pronounced.

Nothing is clipping, adding / deleting or changing parameters doesnt help.

Heres my set up:

Intel Duo 2.6Ghz / 6 GB DDR3 RAM

Pod Farm 2.5 w/ FX Junkie used as stand alone.

UX1 connected via USB replacing my PCs sound card

Fender Strat w/ single coils

Jackson w/ dual humbuckers

Anyone else experience this?

Any suggestions?