Thanks for the suggestions.

First, I removed all connections and reconnected the device. I tried all the USB ports, both on the front and the back of the computer. Then I installed the latest driver (4.2.4.4), still no change. I am not using a USB hub.

Then I went through the troubleshooting guide:

1. Use the latest Line 6 device drivers: Check.

2. Optimize your computer system for audio:  It took a while to go through all those options, but none of them worked.

3. Test all cables: I'm not really sure how to do this. The USB cable seems to work, as the device, UX1, connects and installs fine. The speaker cable also works fine when connected directly to the computer. Also, the guitar jack works fine when used with my amp.

4. Remove USB hubs from your system: Not using any.

5. Adjust the buffer size, sample rate and bit depth in the Line 6 Audio MIDI Control Panel: Check. I tried various settings, but the problem persists.

6. Disable wireless networking devices: I don't have a wireless connection device.

7. Change Power Options: Check.

8. Set your Line 6 device as the main sound card on your system: The link for this is dead, but in step 2 I disabled all other audio devices in the Device Manager.

Step 9 and 10 require me to purchase additional hardware, so I'm not able to try those. And to be honest, additional purchases shouldn't be necessary, your product ought to work on its own.

Hello Don.

Yes, I am using a stereo adapter for my speakers, but I tried with a pair of headphones with a 1/4" jack (although it IS removable) and it's the same deal. The converter I'm using looks like this: