This is from our POD Farm 2.5 Troubleshooting knowledge base document:

http://line6.com/support/docs/DOC-2304

Please try the following:

• Close all open programs out, go to the Mac HD/Users/username/Library/Application Support/Line 6 folder.  ***If you are on Mac OS X Lion 10.7.x, the Library folder is hidden.  To 'unhide' this folder, you must first run the terminal program located in the Applications/Utilities folder.  Once Terminal is running, at the command prompt, type the following:
  • chflags nohidden /Users/Username/Library
    • *The username is the username of your computer which has the house icon under Places
  • Hit enter.  There will be no indication that anything happend except for a new command prompt if it worked.
  • With the Library folder now visible, go to:  Mac HD/Users/username/Library/Application Support/Line 6 folder
• CTRL+Click on that Line 6 folder in that location folder and select GET INFO.  Check the permissions at the bottom of GET INFO, and check to see if they are set to READ ONLY. If so, manually change the permissions to Read & Write.
• Then, run License Manager and just sign in with your Line 6 username.
• After signing in, the Line 6 folder in the above location should be populated with new items such as a Guitarport and License Manager folders, and a L6system file.
• Then, close out License Manager and test POD Farm 2.51 standalone or plug-in once again.

Regards,

Line6Hugo