I have problem with my line 6 gx pod studio. It used to work good but now I hear a lot of sound cracks and noises when I play on my bass or when I liesten to music. Buffer size is super small (notebook asus with duo core 2,4GHz and a lot of RAM.)
You may want to follow the suggestions from our USB Audio Troubleshooting FAQ: http://line6.com/support/docs/DOC-4282. It includes a number of things to try when you run into issues such as this.
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