Sorry for the late reply, but we are still trying to catch up to everybody's posts right now.

Were there any changes to the computer or software at all since this last worked?  Have you tried uninstsalling and re-installing the drivers for the POD?  Which POD do you have?

Do you have any other USB devices connecerted to the computer?  Please remove all other USB devices (except for a mouse and keyboard on a desktop computer) while troubleshooting this problem.  Completely remove ANY USB hubs, even if not in use, and test the hardware on all of your computer's USB ports, preferably the back ports on a desktop system.

You may also want to try all of the tips in the following USB Troubleshooting document:

http://line6.com/support/docs/DOC-4282

Lastly, you should test on another computer to verify if there could just be a problem with the POD hardware itself.

Regards,

Line6Hugo

One thing to try is completely uninstalling your Line 6 MAC OSX drivers using the instructions at the link below:

http://line6.com/support/docs/DOC-2617

If that does not help to establish a connection to the POD the next step as Hugo suggested above is trying to connect the POD to another computer can help to establish if the problem is related your computer or the POD itself.

To do so simply install the latest Line 6 drivers before connecting the POD to the computer:

Windows Drivers 4.2.5.1:

http://line6.com/software/readeula.html?rid=4399

MAC Drivers : 7.1.3

http://line6.com/software/readeula.html?rid=4321

If the POD can not be recognized on the second computer, the problem unfortunately could be with the POD's USB connection, in which case a Line 6 Service Center would need to assess it for repair. To locate one in your area, use the finder at the link below:

http://line6.com/service_centers/