Thanks for the reply.

- Its not on a hub,

- I dont have any other cables as it is an uncommon USB cable type, and didnt/shouldnt need to go buy another just to test that. Its a brand new cable  with the brand new interface and couldnt possibly have worn out/broken...
- No power saving options are on, as I am putting all the power/stability I can into the overclock, which by the way is completely stable and presents no issues.

- Drivers are always up to date. When probelms started, I double checked AND reinstalled new drivers for everything anyway.

- I dont have another PC to try this out on, but Ill see what I can do to try it out.

- and finally, I do overclock. Drawing the power away from motherboard components for the CPU and otherwise seems entirely possible. I have the ability in my BIOS to increase the voltage on the southbridge which would give more power to the components suffering voltage loss (such as USB ports), and as such have tried small increasing increments. I didnt want to increase any voltages until someone actually suggested that I was probably suffering voltage loss across the board.

[EDIT]: So far, with any change in motherboard USB voltages and otherwise is having zero effect. I have at this point literally tried everything, including any suggestions put forward by Line6 and can only sum it up to this - either my motherboard is faulty in the way it delivers stable constant power to the USB slots (although I dont have any other USB problems) or the interface is faulty. I played an .avi file yesterday which presented white noise every 10 seconds or less, and in comparison a YouTube video will blurt white noise every 5 minutes or so. In my studio program (FL 10) It doesnt happen at all some sessions, and other sessions it will be unbearable.

Either way, my ears hurt and I have suffered too many headaches with this thing and I dont know if I have any options left other than to get a new computer or a new interface or both, something I dont really want to do either way.

Since I bought this interface from the US and had it sent here to to AUS, I dont see an RMA happening. What options do I have, assuming my computer legitimately isnt at fault?

Reason for editing: Nothing worked.
Reason for extra edit: What even!?!?!?

Ok EXTRA EDIT
I found this which was one of those regular windows flags outlining issues with my PC. I usually disregard them as Ive already dealt with whatever it says.... although this is what I found. [Direct copy-paste from the proposed 'problem']

Search for a driver for Line 6 TonePort UX2

Your version of Line 6 TonePort UX2 isn't compatible with this version of Windows.

Which version of Windows am I using?

You are using Windows 7.

Line6 may have upgrades or other possible solutions to help make this device compatible with this version of Windows.

So because Im using windows 7, I am therefore incompatible with this entirely? Thats quite a large problem if its true because Win7 has been out for a while now and another windows OS is on its way. Im not going to revert to WinXP or something just to be a little more compatible either. Windows could be wrong and Line6 couldve designed the drivers for Windows 7 (I would hope, because the website driver download says it is) but Windows is saying otherwise and since Im having these problems, Im kinda taking Windows' side here. I am even entirely suspecting that the drivers are bad.