GearBox comes bundled with older drivers, so the first thing I would suggest to check is whether or not your drivers are up to date or not. If you used to Monkey to apply your updates from the top down, your drivers would have been updated and then outdated once you installed GearBox, unless you made sure to uncheck the driver box from the GearBox installer. If you did not uncheck the driver box from the GearBox installer or go back after installing GearBox and reinstall your drivers it is possible they are outdated.

I would suggest that you use the Line 6 Uninstaller located at the location below to remove your currently installed Line 6 drivers:

Windows 7/Vista  -  C:\Program Files(x86)\Line6\Tools -  Line6Uninstaller

Windows XP -  C:\Program Files\Line6\Tools -  Line6Uninstaller

Make sure to disconnect any of your Line 6 USB devices prior to starting the uninstaller. Make sure to only check the boxes at the bottom of the list that are related to the Line 6 drivers, and proceed to uninstall them. Once they are removed, restart the computer. Upon restart download the latest Line 6 Window Drivers from the link below:

Windows Drivers 4.2.5.1:

http://line6.com/software/readeula.html?rid=4399

Make sure not to connect your Line 6 USB device until prompted to so at the end of the installation process. After connecting it, make sure and look towards the Windows system clock for a notification that Windows has detected your device and has successfully installed the drivers before moving forward. If you do not receive this notification message, make sure to try reconnecting the Line 6 hardware to each available USB port until you have exhausted all available USB ports.

Once Windows has detected your device, close all open applications and launch the Line 6 License Manager application. Log into your Line 6 user account, next select your computer on the left hand of the program, de-authorize it and re-authorize it. Next select your Line 6 USB device from the left hand side of program and de-authorize it, you should be given the option to "REMOVE" your licenses from the device, proceed to do so. After that finishes, re-authorize your device and you will be given the option to "INSTALL", proceed to install your software licenses back into your hardware.

Re-open GearBox and try to access the presets that were presenting you with this error.

If you are still experiencing this error messages, close GearBox, disconnect the UX2 and reconnect it to another USB port. Wait for the Windows driver process to finish, once it completes then reopen GearBox and try it again. Make sure to exhaust all USB ports if you still receive the error. If you exhaust all ports, I think the next step would be to try the UX2 on another computer to see if the problem is the UX2 hardware itself or your computer. To do so install the latest drivers onto the test computer to ensure the UX2 is properly set up. Test to see if it happens on the second computer.

Let us know your results.