Hi, OP, firstly I'd like to say that the guitarist you're attempting to emulate is using a Diezel, which is a very high-end amp, thus it will be veeerrrryy difficult to emulate. My best advice is to select a Treadplate amp model. I don't have a 2.0, I have a POD XT Live, but it has the Treadplate Dual amp model, which models a Mesa Dual Rec. It's a distortion that is saturated and has a clean sort of a low-end that doesn't muddy up your sound. If the POD 2.0 has a Treadplate Dual amp model, I would definitely tell you that this may be as close as you can get to the amp in that video.
As far as setting, use set your Bass around 2 o'clock, Mids around 9 o'clock, Treble around 2 or 3 o'clock. Once you have the EQ you desire, begin elevating the Amp volume and Drive back and forth until you find the right volume and Saturation you like. Remember that "more Drive" isn't usually the answer. Be mindful of how it will sound when a full band is playing, as what sounds good playing solo isn't always the same as what sounds good with a full band and your amp cranked to volume. Hope this helps!