I use a PODXT Live to run 2 amps (left and right).
Sometimes the amps will cancel out each other, meaning that one amp will stop working. If I pull the cable out of either channel and push it back in both amps start working again.
I had this problem with my older xt live so I bought another one. After about 2 years I am having this problem with the new one too.
I am running the Champ form the LEFT output and the Roland from the RIGHT output.
2 good instrument cables
Fender Champ 12
Roland Cube 25