I don't know why I never did this before, but there's something to be said for trying things that go against the "rules" with the DT/POD combo.
For instance, I had a pretty decent Marshall tone going on with the P75 preamp on the HD500 using topology II. That's the way it's supposed to work, right? But I'm more of a Mesa kind of guy and I like my "Marshall" tones a little more modern. Switched the topology to IV using the same preamp. Bingo. Right where it needed to be to match up with Crunch mode on CH2 of my Mark V. Has just the right round boldness without annoying top end.
The rules are made for breaking. I've been all smiles for the last couple of hours.