one thing Creamware recommends for their dsp pci cards is to switch off hyperthreading on the pc cpu.
while HT may be great for bit crunching tasks, where one algorhythm is applied to generate a fractal, convert video or whatever, it may introduce latency on the audio signal.
also make sure the cpu/energy settings are configured for optimal performance, not for optimal battery life, where cpu and bus are clocked down for energy saving.
disable all unused hardware like wlan, parallel and serial bus, webcams, firewire, touchscreen, cardreaders in the bios, not in system-hardware.
try getting asio drivers for Your sound chip.
try a lower resolution (800x600 rather than full hd)
latency happens both on the input and output paths, try monitoring the pc input rather than the output, splitting up Your signal before it goes to pc. its a compromise, but will give You an instant response of your playing, the wet signal from pc can then be mixed in. (some effects take some time to build up anyway).