New to the Dream Rig setup, but so far love it. Found a cool way to get a direct out of the Pod HD and have a mic'd DT amp sent to the FOH via one line without any extra summing pre's, mixers, etc. Check it out.
Routing Acoustic Output with Variax, POD HD500, and DT Amps
There's also another option, if you're wanting to bypass the DT for acoustic presets and only run 1 line to your FOH while still using your mic'd DT..
1.) Assign input 1 source to Variax, and assign audio output 1(left) to your DT50.
2.) Make sure your mixer is hard panned left and right in all patches you intend to use.
3.) Assign input 2 to your mic input.
4.) For electric patches, only use the top signal path for guitar effects, amps, etc.
5.) Run your mic line from your mic'd amp to the HD500 mic input, and adjust the input gain accordingly
6.) Run an XLR from the right output of your POD HD to your stage snake or mixer.
7.) If necessary, you can add EQ, Compression and other effects to the lower signal path to alter the mic'd amp's signal.
8.) For acoustic patches, route the variax to input 2, and only use the lower signal path.
This does add a hint more latency for electric patches since you're processing the signal twice, but it's fairly neglegable and allows you more versatility to altering and saving your sound.