In my very humble opinion: using a pod hd 500 in front of a good amp doesn't makes sense!
I see two ways for a musician:
1. you're looking for your very personal sound. Therefor you will search a long time a test a lot of amps till you found your favorite. You put reverb and delay behind the microphon(es) and some modulation in front or behind your amp and that's it
2. you play covers and have to copy a lot of sounds and musician. Then you buy a board like the pod hd 500 and go straight to the FOH or straight into a good stage monitor like the line6 stagesource and then into FOH.
Using your favorite amp with hd 500 is overpowered. It's like having sex with your wife and your lover Maybe you will have some fun, but the girls will make war I tried the pod as a preamp into fx return from my tube combo and I must say: Better use my tube combo alone with a little reverb and use the hd 500 straight to FOH: really, really great sound.
I dial in my sound at home by earphone and make some correction in our rehearsal room. That's the best way.