I don't play nearly as much as most of the above and my sets/gigs aren't nearly as long, but for what it's worth I find the FS5-8 mode much easier to work around. But really it's obviously whatever works best for you.
FS1 - Vol Pedal
FS2 - Compressor
FS3 - Noise Gate
FS4 - Reverb
FS5 - Delay 1 (dotted 8 plus 1/4)
FS6 - Delay 2 (1/4 modulated)
FS7 - Overdrive (screamer)
FS8 - Empty since I use two delays on FS5
This isn't the order of the chain, just the FS. FS1-4 are usually always on, and I set the bottom switches to things I will usually turn on/off like delay and overdrive. I just use one amp/cab/mic combo and feel it works best for most situations (Vox AC30 with Blackback 30, 57 on axis mic). This would of course not be a good setup for metal though.