We're glad to say that all recent Line 6 software and Line 6 hardware drivers work with Windows 11: Helix family, HX family, Amplifi, Firehawk, Spider and Relay products.
Plugins that have been covered are Helix Native, Amp Farm, Echo Farm 3 and Pod Farm 2 against the DAWs Cubase, Pro Tools, Ableton, Studio One and Reaper.
The only outlier is regarding Variax not connecting in Workbench via the Variax USB interface. We will continue to test and report any update here.