My experience using the Helix in live environments is VERY positive. I run it direct to FOH and using wedges, or into a Crate Powerblock and 2 x 12 cab unmiced for very small clubs, or direct to FOH "and" to an on stage amp fx loop/cab, or mic'd cabs with tube amp heads or the power block ... All with great results. You have so many useable options.
There are very few places now that accept cranked tube amps, I have much better results with the Helix. You can dial it in to any type of environment, and for recording, it's amazing
I also had very good results with the Pod X3 Live, and the Helix takes to it all new level, outstanding in my opinion.
You do have to learn how to use the cab mics and high and low cuts and eq's, but once you do .. lookout, fun times.
Small adjustments to amp settings and dirt box settings go a a long way. (large adjustments too).
You can definitely find your "go to" dirt boxes that will please you (I'm partial to the OCD and the fuzzes)
Have fun