On a PC you can't PRACTICALLY (there are workarounds that mostly don't work consistently) use two ASIO devices at once. That means connecting your ID44 and your Helix by USB won't work.
Your ID44 has the ability to do everything you want. I suggest you go to their website and watch all the videos while referencing the manual.
Depending on which Helix you have, you might be able to use the S/PDIF Inputs on the ID44 (need adapter) and eliminate the (pretty much inaudible) AD/DA conversion that would be necessary using the XLR from Helix to ID44.
If you bought your Helix new (or if the previous owner didn't use the discount), you can get a great discount on the Helix NATIVE Plugin. You put that on a track in your DAW, record a clean guitar signal on the track, then process it through NATVE any way you like. No need for traditional re-amping. Helix routing options make this easy, and whatever sound you make on the HW Helix can be duplicated in Native.
After you've done some research on the Audient site and better understand the ID44's capabilities, come back here for answers to specific Helix questions.