Seconded. Just installed Helix Native 3.70 again on nixos, thought I'd swing by and say that this still works great.
Also run it with yabridge, also have switched to wine-tkg[1], which makes it perform even better. I am running on sway on wayland, and also needed dxvk along side the other already suggested dll overrides;
winetricks vcrun2013 gdiplus urlmon dxvk
I think I also left out wininet, like previously mentioned in this thread.
I'll add that on newer kernels, the Helix Floor is also discovered automatically over usb (with pipewire), allowing you to tap in to e.g. channels 7 and 8 for stereo monitoring DI (without effects from the Helix Floor unit), which is great for piping directly into a track with Helix Native in e.g. reaper. Gives you the ability to monitor directly from the Helix Floor unit (with effects) while recording the DI tracks for reamping.
If you have issues logging in after opening the Helix Native plugin, double check that you don't have an existing activation[2] for a machine with the same name. I had to Deauthorize mine before I could log in.
With linux 6.6, pipewire 1.0, reaper, yabridge, wine-tkg, an arturia audiofuse sound card and a 5950x I am able to run a couple of instances of Helix Native and Neural Amp Modeler on a track in reaper while monitoring (off of the track in reaper) without xruns, and reaper reporting a latency of ~1ms. Here's a repo with more of the realtime tweaks I have done, in nix [3]
[1]: https://github.com/Frogging-Family/wine-tkg-git/tree/master/wine-tkg-git
[2]: https://line6.com/account/devices/
[3]: https://github.com/torgeir/nix/