After over 10 hours of installing and reinstalling I finally managed to get the USB Driver to install and run.
Problem:
Workbench installs fine
Line 6 Monkey installs and updates fine but reports no USB Driver
Windows Device Manager reports corrupted or incompatible driver when usb interface is plugged in
The solution:
Click Start, Type Core, Select Core Isolation and run, turn off the Memory Integrity then reboot.
The driver then miraculously functions fine.
Line 6, please pin this somewhere as it was incredibly hard to find a solution and please see if the issue can be addressed.