After watching the video posted this morning (10-15-15) regarding the problem with the Helix and a Mesa V:25 not switching, I wanted to check out my setup.
I ran a 4CM, everything works great with that setup on both a Mesa V:25 and a Mini Rect. Surprised of how quiet it was on clean/dirt even at high gain and volume.
Problem is in the Amp Switch. Using the same cable that was supplied with the Mesa V:25, I get the same results. Amp switch on 1, 2 or 1/2 all do nothing for the channel
It looks like Line 6 is using open collector transistors for switching to ground as opposed to using relays.
There seems to be an isolation problem between the EXT control 1 and EXT control 2 that might be mitigated by increasing the stated 11k resistance. The most reliable way is by using relays, like in the below pic, which I will wire up and test.
The only drawback is that the relays need power, so you will need to provide 9VDC to the interface box.
Seeya
Joe