SOLVED!  Line6 Support worked with me for a while to figure this out.  After performing a fresh install of 'Line 6 Audio-Midi Driver 7.6.8', and restarting my Mac (which is required), I immediately went to System Preferences > Security & Privacy > Click the lock to make changes.  Click the 'Allow' button next to "Some system software was blocked from loading", and then select the Line 6 Audio-Midi Driver.  You only have a few min. after restarting your system to do this before it goes
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