After much digging and a response from Line 6 I've found a way to do this in Reaper.  Just updating this for posterity!   1) Set up a track in Reaper 2) Add the Helix Plugin 3) Open the plugin window 4) Click the + button (next to the No preset drop down and the Param button at the top of the window) 5) Click Link to MIDI program change and choose an option 6) Click the + button again and click Save preset 7) Make another preset 8) Add a MIDI item to