After installing the latest Windows 10 update yesterday (KB5012117), I can't use Helix Native in Reaper. This could be a coincidence, but it's the only thing I can think of that's different from the previous days where it worked.
Reaper opens and other plugins work fine, including Bias 2 and Amplitube 5.
When I click on Helix Native (either VST2 or VST3), it will load the plugin, but clicking on the plugin to bring up the UI causes both the plugin and Reaper to crash.
CPU: AMD Ryzen