Current known fixes:
Uninstall/Reinstall
This goes without saying, essentially turn it off and turn it back on again
Restore Factory Presets
You can attempt to restore Helix Native to factory you will lose your presets but it has worked for some
Computer name changed
Your computer's name may have been changed or if you are on a new machine you may need to go into your line 6 account and deauthorize the old PC and authorize the new PC using Line 6 Lice