I'm having the same problem, with perhaps a twist... In my case, it seems like it's related to whether the HX One was on (not bypassed) when the PC message was sent. If the old preset was bypassed, the preset you change to doesn't work. If it wasn't bypassed, then the new preset will work ok.   I've ended up adding an Engage (leave bypass) message right before the PC, and that works, though i get a momentary glitch before the preset changes, as the old effect breifly switches on.