The bad news:
Autoupdate from within HX Edit may not work, it may display "No update available".
This is not unexpected though, there are barely any apps whatsoever that still get any updates compatible with El Capitan (one noteworthy exception being the brilliant audio tagger Yate!)
According to the Line 6 documentation, MacOS Sierra (10.12) or higher is "required". While that was already their message for earlier updates, this time it's apparently for real.
The good