On a quick look in Helix Native with a random clean sampled guitar MIDI loop in Logic:
The cab has the "160 Ribbon" as a mic profile which sounds rather muddy for a guitar. At least as far as my taste is concerned.
Try the "57 Dynamic" instead. For a rock guitar, you can't go wrong with that. That's what the vast majority of sound guys would place in front of your real cab anyway. Well, I did for s(h)ure while I used to work as a sound guy in the 90s…
Also, you may want to rise the Low Cut a bit. E.g. my guitar presets are usually around 150 Hz. (Me being mainly a bassist, I know how it feels when guitarists or pianists dig in my frequency range. ;)
Also, I'd switch the cab block from the "Legacy" type to the new type which allows for more fine tuning.