https://www.youtube.com/watch?v=JvxTHJ_vl34 This guitar player for Blue Oyster Cult uses the Helix straight into the PA. Rhett Shull a phenomenal player performs with the Helix on stage as well...
I use and have both a Line 6 HD500x as well as some killer pedals like the OCD, MXR analog delay, etc.. Line 6 is particularly known for their exception effects. Frankly TONE comes from your hands and not so much the particular gear you use. A LOT of players keep searching for that special pedal or multi-effect that is going to give them that "killer sound" Most of whom do not realize its your hands that do 90% of the work (of course that assumes you have your gear set up correctly.)