"""In Amplitube you have to choose the POD HD500 ASIO Driver. IF you only want to hear amplitube and not the POD in LINE 6 devices in the monitor TAB, move the volume slider all the way to the left. Now you will only hear amplitube presets. Hi I have done what you recommended and...It worrked a bit. POD HD 500 is silenced but preset from POD 500 disturbing sound of preset from Amplitude.Can u help with this problem please Now remember as long as you USB is connected you will not hear POD HD unless you move that slider back to the right or in case you using a DAW you can activate the monitor on the audio track."""