Dude, thanks a ton! Unfortunately the board part number doesn't match up for some reason (schematic is for 35-00-0137, mine is 35-00-0047), and many of the part numbers and pins don't match what I'm seeing. For example, the resistor in question connects through to pin 7(?) of the VDI plug, which should be AES+, but connects through pin 3 of the main harness, which should be ground. The harness itself should be a 32-pin on the schematic, but on my guitar is a 24-pin. Anyway, according to the schematic, the AES+ line connects straight through to x with no resistor in line, but my board doesn't even have a x on it. R48 leads to a x x diode which leads to an x.
Regardless, the service manual is still super valuable, since it tells me what type of signal goes in and out of the main DSP chip and a few other key chips that are the same on my board as the schematic, but sadly there are way too many differences. Really wish Line 6 made these public.
I agree that I can't expect accurate results measuring in-circuit, but since the schematic doesn't match what I have and the resistor connects straight out to a single pin at the VDI plug there shouldn't be anything in a circuit with it, same as R43 right below it which is a x ohm resistor (marking is x) and measures accurate to 100 ohms, so I'm fairly confident in it's measurement (and in it's crispiness). I think R48 should match R43, since they both connect to the same type of dual diode, but that's REALLY hard to say.
I think that particular pin goes to x on the x which I assume is a chip select of sorts, but I can't find it in the datasheet. Brain hurts...