Thanks so much for the info! That actually sounds like the way to go.
I'm not set on using any particular interface and would gladly use the Helix as my interface. I didn't even think about it to be honest. I just happen to have a Focusrite Scarlett 2i4 but eliminating an extra piece of hardware sounds fine to me.
So with the method you described, would I simply keep my existing 4CM setup but instead of outputting sound to the speaker cab, I would just load the speaker output down with the Reload box and everything else stays the same?
In my current 4CM configuration, the 1/4" Output routes back to my amp head's FX Return Loop and eventually out to the cab (or my Reload box now in this case). So I assume that same signal coming out of the 1/4" Output is also coming out on the USB port? Would I need to make any other configuration changes in the Helix itself or is the signal ready to go and I simply add my IR in the DAW once I have a track setup to monitor the incoming signal?
Thanks again for the help!