Hi Guys,
I had this same problem. But, I have managed to fix it! At least for me. I am using windows 10 to update an Amplifi 75.
First I downloaded the Line 6 updater software.
Then I downloaded the driver.
Then I downloaded the flash memory version 2.50.2
Then, in the line 6 updater utility, I clicked on the 'choose file' button, and manually selected the flash memory file that I'd downloaded. First time I did this, it hung for about a minute till I cancelled it, but at least it was something different so I tried again. Second time....installed no problem! I then did the factory reset, and tried to pair up my Samsung Galaxy tablet....it paired no problem! I've been using it for the last hour, no drop outs, full functionality...I am very happy.
Anyway, I knew how frustrated I was getting, so thought I'd share what I did in case it works for someone else as well.
Good luck!