If you're trying to get an Eric Johnson tone and you're running through a powered speaker or PA system, I think I found the answer. Check it out and let me know if this works for you - http://line6.com/customtone/tone/893870/ I played this through our main PA with a strat and it sounded a lot like his Venus Isle tone. I might dial back the gain a bit to get the Manhattan tone. Alternatively I would add some gain and treble for the Cliffs of Dover tone.
KFURIO's post in Eric Johnson Manhattan tone??? was marked as the answer