Hi wpostma,
Just wondering if you ever got to fix this. I have the same issue on 2 sparate Windows 10 computers (both 20H2). Pod Go Edit 1.21 fails to pick up the device though it is clearly recognised by Windows. Version 101 doesn't work either. Wasted three hours of my life trying to get this to work. Raised a ticket today but not holding out much hope. I assume it is a driver related issue/conflict....? On one machine I am running a Behringer X32 as an interface, on the other a Focusrite. I am sure Line 6 will blame those. I just want to update the firmware, not a lot to ask. If they can't get it working I will be returning the unit. It's a lot of money for something that already has limited capabilities....disappointed.