this is the answer of line 6 on my ticket.
Hi,
This is a macOS issue which appeared after the 10.15.4 update of macOS Catalina (not before on 10.15.3)
This problem is mostly linked to certain hardware only (mostly older Macs from before 2013 )
Unfortunately we can only recommend using macOS versions before 10.15.4 on such setups, there's no information available at the moment about possible macOS fixes
Disconneting and reconnecting the interface stops the freeze
The driver has worked on many other Catalina systems. Our QA department has yet to find the drivers to be incompatible with a Catalina-qualified Mac. In isolated situations like this, we've seen that a configuration issue is usually the root cause of the problem. Unfortunately we are not qualified to diagnose system configurations.
At this point, I'm sorry to say that we have no other suggestions to help resolve the problem.
Best regards,
Line6 Technical Support