It works in Big Sur. Install Line 6 Audio Midi Driver 7.6.8.dmg and like mentioned by sebastiansantos, "Go to system preferences and open the security and privacy tab. On the "allow apps downloaded from" tab click the padlock and allow the Line 6 installation"
Once you've done that, reboot and it will work. I started another guitar software (apparently we're not worthy of Pod 2 Farm license) and it's working flawlessly.