I just went through the same thing. Here's the response from the support ticket that fixed it:
"wvolkmann Mar 8, 08:50 AM We may have found a fix. Please locate this file. This is the path to the interlock file: C:\ProgramData\Line 6\HelixInterlock • Right click/properties on that file. What are the Attributes? • Close the updater, delete HelixInterlock file and re-launch the app. Does it still fail? If so, what are the attributes of HelixInterlock fil
I found it in C:\Users\All Users\Line 6. You may need admin privilege to right click and change the file attributes if it's read only.
Hope it works out.