Thank you for your advice!
I checked the Security & Privacy is setting in Mac App Store and identified developers.
Drivers and the POD HD500X Edit are update
I uninstall and then reinstall the Line 6 Monkey without any issues, restart the computer and when I run the Monkey doesn't work the program don't respond.
This happened only with Line 6 Monkey, the Edit works fine and the drivers are OK, my Mac recognizes the POD HD 500X.