The specs on the site say that it has '1/4†stereo full-range balanced outputs.' This should mean that the Main Outputs will accept a TRS plug. Depending on your setup you could run a 1/4" TRS to 1/4" TRS directly into your board or you could use a TRS to XLR cable or adapter. With either of those setups there should be no need for a direct box.
The Amp Out is unbalanced and would require a direct box to go to a PA. It would not require one to go to a guitar amp.
This is all based on the specs online. I could not find anything in the manual that specified. I do not own this product, so I have not actually tested it.