Hrm.... http://line6.com/support/forum-20/announcement-73-mac-os-1011-el-capitan-problem-with-line-6-usb-audio-driver/
No date/time stamp for accountability on the sticky post. Could be days or months old and only frequent visitors would know.
Only for their "EOL" products it looks like the issue exists. POD 2.0, POD XT, Pocket POD, FloorPODs. Not the FireHawk, HD, Amplify lines.
Reflect on that a moment.