I'm having a similar problem. I have a MacBook Pro with M1 pro and am using Logic Pro running OSX Monterey. I have tried to load Helix Native with and without using Rosetta, and what I get is just a blank screen. The window opens and has me log into my Line 6 account, then the plug-in just has the Line 6 logo at the top, but none of the U/I that accompanies the app. I have deleted and reinstalled Helix Native, and restarted my computer, but every time it just has an empty window. I've owned Helix Native for a few years now and have never had a problem with it in the past.