As an update, I actually did sent the unit back and just received the new one today. Still having the same issues. I've had a support ticket opened for a while, they haven't been able to help much.
To clarify, the Line 6 Pod HD Pro X works fine without being plugged into the computer. I'm able to create, save, edit, etc any tone section I want on the device. When I go to plug in the device to the computer, and launch Line 6 Pod HD Pro X Edit, the unit starts going crazy. It will turn off, power cycle, won't consistently sync individual tones, etc. The most aggrivating part is that when I try and import the entire tone list or individual set lists from the unit to the computer or vice versa, I get error 800000a Connection Time Out. I have a hard time believing I recieved two defective units, and I've tried almost everything I can imagine. Different USB ports, different USB cords, and I've completed the USB Troubleshooting steps the document here at Line 6 provides. I'm starting to think its an issue with my computer, but I can't understand what it would be. I have no other issues with anything else run by USB. Any suggestions would be fantastic.