I saw your post while trying to fix a similar problem. This worked for me: After I installed all the latest upgrades to the drivers and the editor, I restarted the system then followed these steps. 1. Open System Preferences in OS X Catalina 2. Select "Security and Privacy" 3. Select the "General" tab 4. Look at the bottom for an alert about system software prevented from loading 5. Select to allow software from Line 6 6. Open POD HD500 Editor 7. Connect the POD to the USB Done! I hope this helps!