For anyone else stumbling across this thread in the future.
I tried unsuccessfully resetting a PODxt Live, had to switch off Core Isolation Memory Integrity to install the driver L6PODLV64.sys.
But once the driver was installed I still had problems & couldn't get Line 6 Monkey or Line 6 Edit to work.
After I gave up I uninstalled all the Line 6 programs using the uninstaller but it left the file L6PODLV64.sys which is the incompatible driver so couldn't reenable Memory Integrity.
I tried Georgie's suggestions above, went to windows/system32 and deleted L6DriverControlPanel. cpl (or very similar file name) but there was no sign of the .sys file.
I tried CCleaner which didn't help.
Ran Windows Registry Editor, searched for the file, found it but it wouldn't let me delete it. However this did give me the file location.
Went to Windows/System32/drivers and deleted the file from there. Was able to switch on Memory Integrity after that.