Thank you for that.
Yes, I thought that it might be a problem, which is why I asked this in my opening post. If I understand it correctly, the mic/backing track part can't operate totally independent from patch changes.
But for the sake of simplicity: If I were to use only one good amp model throughout the evening, and then use the Helix in a sort of stomp mode (just like I would with my current rig, which is an analog pedalboard and an amp), and turn on and off the effects I'd need, would this too effect the mic/backing track side?